Copyright 2023 IBM Watson Health. Should I avoid certain foods while taking Isosorbide Mononitrate? Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Garlic. It can cause your blood pressure to become dangerously low. Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Merus Labs Luxco S.a.R.L, The electronic Medicines Compendium. The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. It works and leaves the body quickly, so it needs to be taken twice a day. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. PMC Compare a few possible alternatives below. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Which drugs or supplements interact with isosorbide mononitrate? Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. Conclusions: Store it at room temperature and away from excess heat and moisture (not in the bathroom). Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. It might help to keep the room cool and use a fan. 5.0 out of 10 from a total of "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. In the US - Call your doctor for medical advice about side effects. The tablet usually is taken two or three times daily. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Alcohol can make the side effects from isosorbide worse. (2) One in 3 patients never experienced headache from the given dosages. Yes, it's good for health but don't take it excesse in amount, use once daily for 1 month then stop it or take once a weekly. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Enter other medications to view a detailed report. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. Aspirin relieves pain and inflammation and helps to thin the blood. Duplication for commercial use must be authorized by ASHP. WebMD does not provide medical advice, diagnosis or treatment. Nitrate-induced headache in patients with stable angina pectoris Accessed Sept. 7, 2022. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Headache is often a sign that this medication is working. Store in a cool, dry place, away from direct heat and light. Methods: isosorbide mononitrate (Rx) Brand and Other Names: Imdur, Monoket, more. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. This site needs JavaScript to work properly. Change positions slowly until your body is used to the medication. The use of the Truven Health products is at your sole risk. My cardiologist recommended I get on metropolol. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Available for Android and iOS devices. This content does not have an English version. This medicine is available only with your doctor's . All rights reserved. Things to remember when you fill your prescription. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. See also: nitroglycerin side effects in more detail. It can make you really dizzy. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. This is so your doctor can check on your progress. May also be prescribed off label for Esophageal Spasm. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage. Careers. 72% of reviewers reported a positive effect, while 12% reported a negative effect. As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. In: Current Medical Diagnosis & Treatment 2022. Is not subject to the Controlled Substances Act. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. The IR version can help treat and prevent angina. It can cause your blood pressure to become dangerously low. Please note that only the generic name of each medication is listed below. Isosorbide is in a class of medications called vasodilators. Your health care provider and pharmacist can help you stay away from unsafe interactions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Take care, thanks. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Accessibility Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Otherwise, call a poison control center right away. This content does not have an Arabic version. It is best not to drink alcohol while you are on isosorbide mononitrate. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. If you have ever had an allergic reaction to a medicine. Saw palmetto. Ask your pharmacist any questions you have about refilling your prescription. Be sure to mention any of the following: aspirin; beta blockers such as atenolol (Tenormin, Tenoretic), carteolol , labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), sotalol (Betapace, Sorine, Sotylize), and timolol; calcium channel blockers such as amlodipine (Norvasc, in Amturnide, in Tekamlo), diltiazem (Cardizem, Cartia, Dilt-CD, others), felodipine (Plendil), isradipine, nifedipine (Adalat CC, Afeditab, Procardia), and verapamil (Calan, Covera, Verelan); ergot-type medications such as bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (D.H.E. Accessed Sept. 7, 2022. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Ginkgo. Last Revised - 09/15/2019. Nitroglycerin has an average rating of Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Isosorbide may not work as well after you have taken it for some time or if you have taken many doses. Coenzyme Q-10 Natural Medicines. Do not share this medication with others. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. Isosorbide mononitrate. Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease. Dehydration in Buspar, how severe and when it was recovered? Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. Treatment and prognosis of heart failure with preserved ejection . Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). What happens if I stop taking isosorbide mononitrate (Monoket)? And as many as 25% of people also take medicines ordered for them by their health care providers, also called prescription medicines. Cleophas TJ, Niemeyer MG, van Der Wall EE. Does Isosorbide Mononitrate interact with other medications? https://naturalmedicines.therapeuticresearch.com. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). You will find a full list in the manufacturer's information leaflet supplied with your medicine. This is not a complete list of possible side effects. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. Read our editorial policy. Be sure to talk to your health care provider before you take any herbal supplements if you take prescription medicines. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention.